| Expression pattern: |
UP |
| Associated gene: |
BRIP1 |
| Associated microRNA: |
- |
| Biological function: |
associated with imatinib resistance, tumor relapse and progression, and metastasis |
| Molecular mechanism: |
not specified |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; ISH (In Situ Hybridization); Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
diagnostic biomarker for distinguishing imatinib-naïve tumors from imatinib-resistant tumor tissues (ROC AUC 0.759); high expression associated with shorter survival |
| Description: |
circ-BRIP1 (circ_0045015) is upregulated in imatinib-resistant GIST tissues and correlates with resistance and aggressive clinical features (relapse/progression/metastasis). ISH shows nucleus/cytoplasm positivity in malignant tumor cells, and high circ-BRIP1 expression is associated with worse survival. |
| Confidence score: |
0.7277 |