circRNA basic information
circBase ID: -
Name: hsa_circ_PRDM2
Synonym: circPRDM2
Host Gene: PRDM2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005180
MONDO name: Parkinson disease
Disease details: Parkinson’s disease / PD
Disease DO ID:
14330
Disease MeSH ID:
D010300
Disease NCIt ID:
C26845
Disease ICD11 ID:
296066191
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood

Cell lines:

-

In vivo animal model:

-

circRNA-disease information
Expression pattern:
UP
Associated gene: CACNG8
Associated microRNA: -
Biological function: Positively associated with (and predicted to regulate) up-regulated target mRNA expression in a stage-specific PD ceRNA network (V04).
Molecular mechanism: Predicted ceRNA regulation within a circRNA-miRNA-mRNA network (computationally inferred; interactions not experimentally validated).
Biological pathway or process:

ceRNA regulation (other)

Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis

Clinical significance:

Potential stage-specific biomarker/therapeutic target candidate (computational prediction).

Description:

circPRDM2 is computationally identified from whole-blood RNA-seq as uniquely up-regulated at the V04 PD stage and is predicted to participate in a stage-specific ceRNA network, showing positive correlation with the up-regulated target mRNA CACNG8.

Confidence score:

0.1768

Other information
Title:

Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson's disease.

Journal: Molecular brain
Published: 2025
PubMed ID: 41327336
Study type:

bioinformatics study

Data availability: PPMI (https://www.ppmi-info.org/); supplementary material available at 10.1186/s13041-025-01262-2
Code availability: -