circRNA basic information
circBase ID: hsa_circ_0092310
Name: hsa_circ_TJAP1
Synonym: circTJAP1
Host Gene: TJAP1
Genomic location(hg19): chr6:43467278-43467478:+
Genomic location(hg38): chr6:43499540-43499740:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: potential diagnostic biomarker (AUC reported but not significant)
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

ROC AUC 0.6143 for distinguishing CRC from controls (35 paired samples); P = 0.1103
Description:

circTJAP1 (hsa_circ_0092310) is elevated in CRC plasma exosomes in the initial validation set; its ROC performance was low and not statistically significant (AUC 0.6143, P = 0.1103).
Confidence score:

0.4187
Other information
Title:

Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer.

Journal: Translational oncology
Published: 2023
PubMed ID: 36934637
Study type:

combined biological and clinical study
Data availability: -
Code availability: -