| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes colon cancer cell migration |
| Molecular mechanism: |
Loss-of-function (shRNA knockdown) suggests a pro-migratory role; downstream mechanism not specified for this circRNA. |
| Biological pathway or process: |
migration (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Transfection; Transwell Assay |
| Clinical significance: |
Included in a four-circRNA-based cirScore that stratifies recurrence risk and is associated with shorter DFS and OS in high-risk (high cirScore) patients. |
| Description: |
hsa_circ_0122319 is overexpressed in recurrent stage II/III colon cancer and in colon cancer cell lines. Its knockdown suppresses colon cancer cell migration, supporting a pro-metastatic role; it also contributes to a four-circRNA cirScore that predicts recurrence risk and worse survival when high. |
| Confidence score: |
0.8004 |