| Expression pattern: |
UP |
| Associated gene: |
CREB1 |
| Associated microRNA: |
miR-433-3p |
| Biological function: |
circMBOAT2 promotes bladder cancer cell proliferation and migration; knockdown of circMBOAT2 inhibits the growth and migration of Bca cells. |
| Molecular mechanism: |
circMBOAT2 acts as a cytoplasmic miRNA sponge for miR-433-3p and increases CREB1 expression via the miR-433-3p/CREB1 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; MTT; Wound Healing Assay; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
circMBOAT2 expression is positively correlated with unfavorable prognosis, larger tumor size and lymph nodes metastasis, and may serve as a tumor biomarker and therapeutic target for Bca. |
| Description: |
circMBOAT2 is up-regulated in bladder cancer tissues and cells and is associated with adverse clinicopathological features and poor prognosis. Functionally, circMBOAT2 promotes proliferation and migration of bladder cancer cells. Mechanistically, cytoplasmic circMBOAT2 sponges miR-433-3p to modulate the CREB1 axis, suggesting biomarker and therapeutic-target potential. |
| Confidence score: |
0.7785 |