| Expression pattern: |
UP |
| Associated gene: |
Wnt1, beta-catenin |
| Associated microRNA: |
miRNA-29a |
| Biological function: |
May affect the pathogenesis of nonalcoholic steatohepatitis and may serve as a therapeutic target; its upregulation is associated with downregulated miRNA-29a and reduced Wnt/beta-catenin pathway expression. |
| Molecular mechanism: |
circRNA-HIPK3 may act as a miRNA-29a sponge and influence the Wnt/beta-catenin pathway in NASH. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); lipid metabolism (other); ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
May be used as a therapeutic target for nonalcoholic steatohepatitis. |
| Description: |
circRNA-HIPK3 was upregulated in plasma from NASH patients compared with controls. The study proposes that circRNA-HIPK3 may sponge miRNA-29a and participate in NASH pathogenesis through reduced Wnt/beta-catenin signaling, making it a potential therapeutic target. |
| Confidence score: |
0.2995 |