| Expression pattern: |
UP |
| Associated gene: |
SCARB1 |
| Associated microRNA: |
miR-1272 |
| Biological function: |
Promotes ccRCC cell proliferation, migration, invasion, EMT and tumor growth in vivo, while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0003146 acts as a miR-1272 sponge to upregulate SCARB1 expression, thereby promoting malignant progression of ccRCC. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; CCK8; Western Blot; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Circ_0003146 is promising to be a molecular target for ccRCC diagnosis and treatment. |
| Description: |
circ_0003146 is up-regulated in ccRCC tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis, mainly through the circ_0003146/miR-1272/SCARB1 ceRNA axis. The study suggests circ_0003146 may be a molecular target for ccRCC diagnosis and treatment. |
| Confidence score: |
0.786 |