| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker for IBD (UC and CD); increased serum CircUHRF1 in UC/CD compared with controls and CRC. |
| Molecular mechanism: |
Not experimentally defined in this study; discussed in relation to UHRF1-associated DNA methylation/epigenetic regulation and immune/NK-cell-related hypotheses. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Serum CircUHRF1 is significantly overexpressed in UC and CD and can differentiate IBD from CRC and healthy controls by ROC analysis. |
| Description: |
CircUHRF1 is up-regulated in serum of UC and CD patients, supporting its use as an IBD biomarker and for distinguishing IBD from CRC and healthy controls. The study does not provide direct functional/mechanistic validation; mechanistic explanations are discussed based on its host gene UHRF1 and prior literature. |
| Confidence score: |
0.4187 |