| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-182-5p |
| Biological function: |
Potential diagnostic biomarker; expression was significantly higher in an immortalized human liver cell line than in several HCC cell lines. |
| Molecular mechanism: |
Bioinformatically predicted circRNA-miRNA-mRNA interaction network; hsa-miR-182-5p was predicted as the most likely target miRNA. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Good performance in discriminating HCC tissues from normal tissues; AUC = 0.978. |
| Description: |
circGNAO1 was significantly downregulated in HCC tissues and showed strong diagnostic performance for distinguishing HCC from adjacent normal tissues. Bioinformatics analysis predicted hsa-miR-182-5p as its most likely target miRNA, suggesting a possible ceRNA-related role. |
| Confidence score: |
0.6841 |