| Expression pattern: |
UP |
| Associated gene: |
Mcl-1 / MCL-1 |
| Associated microRNA: |
- |
| Biological function: |
circ_0067934 functions as an oncogene in breast cancer, enhances BC cell proliferation, regulates BC cell cycle, and promotes tumorigenesis by upregulating MCL-1. |
| Molecular mechanism: |
circ_0067934 upregulates Mcl-1/MCL-1 expression at the mRNA and protein levels, thereby promoting breast cancer cell proliferation and cell cycle progression. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0067934 could serve as a promising marker for BC; circ_0067934 expression was significantly correlated with tumor stage and lymph node metastasis. |
| Description: |
In this study, circ_0067934 was up-regulated in breast cancer tissues and cell lines. Knockdown experiments indicated that circ_0067934 promotes breast cancer cell viability, colony formation, proliferation, and cell cycle progression, at least partly by upregulating MCL-1. The paper also suggests circ_0067934 may be a promising marker for breast cancer. |
| Confidence score: |
0.5751 |