| Expression pattern: |
DN |
| Associated gene: |
EIF4A3, APC |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
inhibits GC cell proliferation, migration/invasion, metastasis, and EMT; suppresses tumor growth and metastasis in vivo |
| Molecular mechanism: |
EIF4A3 mediates circ_0008126 biogenesis; circ_0008126 sponges miR-502-5p to derepress APC and inactivate beta-catenin signaling; circ_0008126 binds cytoplasmic EIF4A3 to enhance APC mRNA stability |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); Wnt/beta-catenin (inhibits); ceRNA regulation (promotes); mRNA stability (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Clinical Sample Validation; Survival Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
Low expression of circ_0008126 was associated with increased lymphatic metastasis, advanced TNM stage, and shorter survival in GC patients. |
| Description: |
circ_0008126 is down-regulated in gastric cancer and acts as a tumor suppressor. It inhibits proliferation, EMT, and metastasis by sponging miR-502-5p to increase APC and suppress Wnt/beta-catenin signaling, and by binding EIF4A3 to enhance APC mRNA stability. Low circ_0008126 expression is associated with lymphatic metastasis, advanced TNM stage, and poorer survival. |
| Confidence score: |
0.8892 |