| Expression pattern: |
UP |
| Associated gene: |
IGF1R |
| Associated microRNA: |
miR-140-5p |
| Biological function: |
Promotes TGCT cell proliferation, colony formation and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-140-5p to upregulate IGF1R. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Transfection; Luciferase Reporter Assay; RNA Pull-Down; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circNOLC1 expression correlates with advanced clinical stage, pathological grade, and lymph node metastasis in TGCT patients. |
| Description: |
circNOLC1 is up-regulated in TGCT and promotes malignant phenotypes (proliferation/colony formation/invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging miR-140-5p to increase IGF1R expression, and its high expression is associated with more advanced clinicopathological features. |
| Confidence score: |
0.7945 |