circRNA basic information
circBase ID: hsa_circ_0020123
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:119042605-119049859:-
Genomic location(hg38): chr10:117283094-117290348:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue; adjacent normal lung tissue; cancer tissues; matched normal lung tissues
Cell lines:

PC9; H1573; A549; SK-MES-1; H1299; Calu-3; HEK-293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ZEB1, EZH2, AGO2
Associated microRNA: miR-144
Biological function: hsa_circ_0020123 acts as an oncogenic circRNA in NSCLC, promoting proliferation, migration, invasion, tumor growth and metastasis, while inhibiting apoptosis.
Molecular mechanism: hsa_circ_0020123 functions as a competing endogenous RNA by sponging miR-144, thereby upregulating ZEB1 and EZH2.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; In Vivo Animal Model; H&E Staining; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Microarray; Bioinformatics Analysis
Clinical significance:

Up-regulation of hsa_circ_0020123 is associated with poor differentiation degree, lymph node metastasis, high TNM stage and poor prognosis; it may serve as a prognosis predictor and therapeutic target for NSCLC.
Description:

hsa_circ_0020123 is up-regulated in NSCLC tissues and is associated with advanced clinicopathological features and poor overall survival. Functionally, it promotes NSCLC proliferation, migration, invasion, tumor growth and metastasis and inhibits apoptosis. Mechanistically, it sponges miR-144 to increase ZEB1 and EZH2 expression, forming a hsa_circ_0020123-miR-144-ZEB1/EZH2 ceRNA axis.
Confidence score:

0.798
Other information
Title:

A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer.

Journal: American journal of cancer research
Published: 2018
PubMed ID: 30210911
Study type:

combined biological and clinical study
Data availability: -
Code availability: -