| Expression pattern: |
DN |
| Associated gene: |
KAT7, FOXO1, FOXO3a, H4K5ac, p21, p27, Twist1, E-cadherin |
| Associated microRNA: |
- |
| Biological function: |
Suppresses proliferation and invasion/metastasis of gastric cancer cells; induces G1 cell cycle arrest; inhibits tumor growth and lung metastasis in vivo. |
| Molecular mechanism: |
Acts as a modular scaffold recruiting histone acetyltransferase KAT7 to FOXO1/FOXO3a promoters, increasing H4K5 acetylation and activating FOXO1/FOXO3a transcription, altering downstream targets (p21, p27, Twist1, E-cadherin). |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); metastasis (inhibits); cell cycle (inhibits); FOXO signaling (promotes); other pathway/process (promotes); histone modification (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; ISH (In Situ Hybridization); Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Transfection; CCK8; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); ChIP / ChIP-seq; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Lower expression of circMRPS35 is associated with shorter survival time in gastric cancer patients; circMRPS35 expression is related to clinicopathological characteristics and prognosis. |
| Description: |
circMRPS35 (hsa_circ_0000384) is down-regulated in gastric cancer and functions as a tumor suppressor. It localizes mainly in the nucleus and scaffolds KAT7 to FOXO1/FOXO3a promoters to increase H4K5 acetylation, thereby transcriptionally activating FOXO1/FOXO3a and downstream genes (p21/p27, Twist1, E-cadherin) to inhibit proliferation, cell-cycle progression, invasion and metastasis. Low circMRPS35 expression is associated with worse patient survival. |
| Confidence score: |
0.9043 |