circRNA basic information
circBase ID: -
Name: hsa_circ_FARSA
Synonym: circFARSA / circular Phenylalanyl-tRNA Synthetase Subunit Alpha
Host Gene: FARSA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma extracellular vesicle-enriched samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: PTEN
Associated microRNA: -
Biological function: promotes invasion; promotes metastasis
Molecular mechanism: via the PTEN/PI3K/AKT axis
Biological pathway or process:

PI3K/AKT (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Others
Validation methods:

Bioinformatics Analysis; ROC Analysis
Clinical significance:

Included in a 10-circRNA signature able to discriminate LC from controls (AUC ROC 0.86).
Description:

circFARSA is part of a plasma EV-circRNA 10-feature machine-learning signature for early-stage NSCLC detection (AUC ROC 0.86). The paper does not report its expression direction in this cohort, but notes prior evidence that circFARSA promotes invasion and metastasis via the PTEN/PI3K/AKT axis.
Confidence score:

0.2629
Other information
Title:

Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.

Journal: Pharmaceutics
Published: 2022
PubMed ID: 36297470
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author (carlospedraz@icloud.com) upon reasonable request.
Code availability: -