| Expression pattern: |
UP |
| Associated gene: |
CDK6 |
| Associated microRNA: |
miR-770-5p |
| Biological function: |
Promotes gastric cancer cell viability, migration, invasion, and xenograft tumor growth; circ_ASAP2 knockdown inhibits these malignant phenotypes. |
| Molecular mechanism: |
circ_ASAP2 functions as a miR-770-5p sponge to positively regulate CDK6 expression, thereby promoting gastric cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Potential circRNA-targeted therapeutic strategy for gastric cancer treatment. |
| Description: |
circ_ASAP2 is up-regulated in gastric cancer tissues and cell lines. It promotes GC cell viability, migration, invasion, and xenograft tumor growth by sponging miR-770-5p and positively regulating CDK6, suggesting potential therapeutic relevance. |
| Confidence score: |
0.7404 |