| Expression pattern: |
UP |
| Associated gene: |
FOXM1, beta-catenin, c-Myc, Ago2 |
| Associated microRNA: |
miR-375 |
| Biological function: |
enhances 5-FU resistance and promotes colony formation and invasion in 5-FU-resistant CRC cells |
| Molecular mechanism: |
circ-PRKDC acts as a sponge for miR-375 to increase FOXM1 expression and activate Wnt/beta-catenin signaling (beta-catenin, c-Myc), thereby promoting 5-FU resistance |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); chemoresistance (promotes); invasion (promotes); proliferation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circ-PRKDC level was related to TNM grades, lymph node metastasis and tumor size |
| Description: |
circ-PRKDC (circ_0136666) is up-regulated in 5-FU-resistant colorectal cancer tissues and cells and promotes 5-FU chemoresistance. Mechanistically, it sponges miR-375 to increase FOXM1 and activates Wnt/beta-catenin signaling (beta-catenin, c-Myc), enhancing colony formation and invasion; its knockdown sensitizes tumors to 5-FU in a xenograft model. |
| Confidence score: |
0.7412 |