circRNA basic information
circBase ID: hsa_circ_0000227
Name: hsa_circ_ZEB1
Synonym: -
Host Gene: ZEB1
Genomic location(hg19): chr10:31644072-31676195:+
Genomic location(hg38): chr10:31355143-31387266:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

brain tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Predicted to affect essential genes’ expression through sponging miRNAs in GBM.
Molecular mechanism: ceRNA (miRNA sponging) mechanism (predicted).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000227 is up-regulated in GBM microarray datasets and was included in a predicted ceRNA network. The study suggests it may act as a miRNA sponge to influence downstream mRNA expression, but provides no experimental validation.
Confidence score:

0.1768
Other information
Title:

Integrative analysis of glioblastoma multiforme: the power of non-coding RNAs and hub genes in cancer research.

Journal: Clinical and experimental medicine
Published: 2025
PubMed ID: 40317362
Study type:

bioinformatics study
Data availability: GSE109569; GSE165926
Code availability: -