| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Acts as a circulating plasma diagnostic biomarker for CRC; correlated with tumor size, TNM stage, lymph node metastasis, and distant metastasis. |
| Molecular mechanism: |
Not mechanistically tested; plasma levels were positively correlated with intratumoral levels and decreased after tumor resection, suggesting tumor-derived circulating circRNA. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Upregulated plasma hsa_circ_0001900 had diagnostic value for CRC with AUC 0.722 and was correlated with tumor size, TNM stage, lymph node metastasis, and distant metastasis. |
| Description: |
hsa_circ_0001900 is upregulated in plasma and CRC tumor tissues of CRC patients. It was validated by qRT-PCR and Sanger sequencing and showed diagnostic utility for distinguishing CRC from non-CRC samples, especially as part of the three-circRNA CircPanel. |
| Confidence score: |
0.63 |