| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Serves as a non-invasive diagnostic biomarker for cervical cancer and early-stage cervical cancer; high postoperative serum expression correlates with tumour relapse. |
| Molecular mechanism: |
Not investigated in this study; circular structure was confirmed by RNase R resistance. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study |
| Clinical significance: |
Highly expressed circ_0000285 from serum and cervical exfoliated cells may be a diagnostic biomarker for ESCC and CC; high serum circ_0000285 after surgery is associated with tumour relapse; high expression is positively correlated with SCC-Ag level and HPV positive rate. |
| Description: |
This study found that circ_0000285 is up-regulated in serum and cervical exfoliated cells from cervical cancer patients and in cervical cancer cell lines. Its expression shows diagnostic value for CC and ESCC, is superior to CA125 and SCC-Ag in ROC analysis, and high postoperative serum levels are associated with tumour relapse. |
| Confidence score: |
0.5727 |