circRNA basic information
circBase ID: hsa_circ_0005232
Name: hsa_circ_SLC8A1
Synonym: circSLC8a1 / circLSC8a1
Host Gene: SLC8A1
Genomic location(hg19): chr2:40655612-40657441:-
Genomic location(hg38): chr2:40428472-40430301:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005252
MONDO name: heart failure
Disease details: heart failure / HF
Disease DO ID:
 -
Disease MeSH ID:
 D006333
Disease NCIt ID:
 C50577
Disease ICD11 ID:
 1458683894
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

heart tissues
Cell lines:

293T; HEK293T; AC16; HL-1
In vivo animal model:

genetically engineered animal model; other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: POLRMT, TIMM50
Associated microRNA: -
Biological function: promotes cardiac remodelling and heart failure phenotypes; decreases heart function; promotes fibrosis
Molecular mechanism: circRNA translation into SLC8a1-604; SLC8a1-604 translocates to mitochondria and binds POLRMT (with TIMM50), downregulating mitochondrial gene transcription and reducing ATP synthesis
Biological pathway or process:

mitochondrial function (inhibits); oxidative phosphorylation (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Western Blot; Nuclear-Cytoplasmic Fractionation; Transfection; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Luciferase Reporter Assay; Bioinformatics Analysis; RNA-seq; Clinical Sample Validation; In Vivo Animal Model; FISH / smFISH; ISH (In Situ Hybridization); IF (Immunofluorescence); ELISA
Clinical significance:

circSLC8a1 is significantly increased in heart failure patients and is suggested as a therapeutic target
Description:

In heart failure/cardiac pressure-overload remodelling, circSLC8a1 is up-regulated and exerts pathogenic effects mainly by being translated into SLC8a1-604. The translated protein interacts with TIMM50 and POLRMT in mitochondria to repress mitochondrial gene transcription and ATP production, contributing to impaired cardiac function and remodelling/fibrosis.
Confidence score:

0.7766
Other information
Title:

A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodelling.

Journal: Cardiovascular research
Published: 2025
PubMed ID: 40273295
Study type:

combined biological and clinical study
Data availability: The data underlying this article will be shared on reasonable request to the corresponding author.
Code availability: -