| Expression pattern: |
UP |
| Associated gene: |
MYO6, MEK1/2, ERK1/2, CDK1, Cyclin D1, Ago2 |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
Circ_0011385 acts as an oncogene in CRC, promoting cell proliferation, colony formation, migration, invasion, cell cycle progression and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
Circ_0011385 sponges miR-330-3p to regulate MYO6 expression and activate the MEK1/2/ERK1/2 signaling pathway in CRC. |
| Biological pathway or process: |
ERK (promotes); MAPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circ_0011385 expression was associated with tumor size, TNM stage and lymph node metastasis of CRC patients, and was reported as an independent predictor for overall survival; the study suggests it may be a therapeutic target for CRC. |
| Description: |
Circ_0011385 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It promotes CRC cell proliferation, migration, invasion, cell cycle progression and xenograft tumor growth while suppressing apoptosis, mainly through the miR-330-3p/MYO6 axis and MEK1/2/ERK1/2 signaling pathway. |
| Confidence score: |
0.8645 |