| Expression pattern: |
UP |
| Associated gene: |
TOP2A |
| Associated microRNA: |
miR-1270 |
| Biological function: |
Promotes NSCLC cell proliferation and migration and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1270 to regulate TOP2A expression; validated by rescue experiments and dual-luciferase reporter assays. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Clinical Sample Validation |
| Clinical significance: |
circ_0072088 may serve as a potential biomarker for non-small cell lung cancer. |
| Description: |
This study reports that circ_0072088 is up-regulated in NSCLC and promotes malignant phenotypes (proliferation and migration) while inhibiting apoptosis. Mechanistically, circ_0072088 functions as a ceRNA by sponging miR-1270 to increase TOP2A expression, forming a circ_0072088/miR-1270/TOP2A axis. |
| Confidence score: |
0.6777 |