| Expression pattern: |
UP |
| Associated gene: |
ACTA2, CTGF, POSTN, SMAD2/3 |
| Associated microRNA: |
miR-30a-5p, miR-125b-5p |
| Biological function: |
promotes cardiac fibroblast activation and pro-fibrotic marker expression; supports TGF-beta1-induced fibrosis signaling |
| Molecular mechanism: |
circPVT1 binds miR-30a-5p and miR-125b-5p and modulates their cellular bioavailability, leading to deregulation of miRNA mRNA targets; regulates TGF-beta1-SMAD signaling |
| Biological pathway or process: |
fibrosis (promotes); TGF-beta/SMAD (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNA-seq; RNA Pull-Down; Transfection; ddPCR; Western Blot; Bioinformatics Analysis; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circPVT1 was upregulated in the left ventricle of ischemic heart failure patients compared to non-ischemic controls. |
| Description: |
circPVT1 is up-regulated in the left ventricle of ischemic heart failure patients and increases in fibrotic conditions (TGF-beta1-stimulated human cardiac fibroblasts). Functionally, circPVT1 promotes cardiac fibroblast activation and pro-fibrotic marker expression, at least partly by binding miR-30a-5p and miR-125b-5p and modulating miRNA target-gene repression and TGF-beta/SMAD signaling. |
| Confidence score: |
0.8012 |