| Expression pattern: |
UP |
| Associated gene: |
KDM2A, NFATC3, PCNA, MMP9, Bcl-2, Bax |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
promotes cervical cancer cell proliferation, migration, invasion, metastasis and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circ_0005615 acts as a ceRNA by sponging miR-138-5p to positively regulate KDM2A expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0005615 may be a potential target for the treatment of CC |
| Description: |
circ_0005615 is up-regulated in cervical cancer tissues and cells and functions as an oncogenic circRNA. It promotes CC cell growth, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0005615 sponges miR-138-5p to increase KDM2A expression, forming a circ_0005615/miR-138-5p/KDM2A regulatory axis that may represent a therapeutic target. |
| Confidence score: |
0.844 |