| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for NSCLC and dynamic monitoring marker; associated with tumor progression and clinicopathological parameters. |
| Molecular mechanism: |
Subcellular localization suggests potential ceRNA (miRNA sponge) and RBP-interaction mechanisms; downstream miRNAs/RBPs and circRNA-miRNA-mRNA and circRNA-RBP networks were predicted by bioinformatics without experimental validation. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; In Vivo Animal Model; Cohort Study |
| Clinical significance: |
circIARS is increased in NSCLC plasma/tissues and shows diagnostic performance (ROC AUC 0.778) superior to CEA, SCC and Cyfra21-1; decreases after chemotherapy/surgery and increases after recurrence for dynamic monitoring; high expression correlates with several clinicopathological parameters (e.g., TNM stage, metastasis). |
| Description: |
circIARS (hsa_circ_0006702, from IARS) is up-regulated in NSCLC tissues and plasma and shows good diagnostic performance versus controls and other lung disease groups. Its level decreases after chemotherapy/surgery and increases after recurrence, supporting use for dynamic monitoring; mechanistically, it localizes to both nucleus and cytoplasm and is predicted (bioinformatically) to act via ceRNA and/or RBP-associated networks. |
| Confidence score: |
0.7844 |