circRNA basic information
circBase ID: hsa_circ_0005379
Name: hsa_circ_GDI2
Synonym: circGDI2 / circ_0005379
Host Gene: GDI2
Genomic location(hg19): chr10:5827104-5842668:-
Genomic location(hg38): chr10:5785141-5800705:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent healthy tissues; xenograft tumors
Cell lines:

Li-7; Huh-7; THLE-2; Hep G2; Hep 3B2.1-7
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2BP2, PKM2, FTO
Associated microRNA: -
Biological function: promotes HCC cell proliferation and glycolysis; promotes tumor growth
Molecular mechanism: FTO-mediated m6A modification enhances circGDI2 stability/expression; circGDI2 interacts with the m6A reader IGF2BP2 and regulates/stabilizes PKM2 mRNA, promoting glycolysis and proliferation
Biological pathway or process:

glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); m6A modification (other); mRNA stability (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Luciferase Reporter Assay; MeRIP / MeRIP-seq; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis
Clinical significance:

circGDI2 as a potential therapeutic target for HCC
Description:

circGDI2 is up-regulated in hepatocellular carcinoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC proliferation, glycolysis, and tumor growth by interacting with the m6A reader IGF2BP2 to enhance PKM2 expression/stability, while FTO-dependent m6A modification increases circGDI2 stability and expression, reinforcing the circGDI2-IGF2BP2-PKM2 axis.
Confidence score:

0.817
Other information
Title:

The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification.

Journal: Non-coding RNA research
Published: 2026
PubMed ID: 41439029
Study type:

combined biological and clinical study
Data availability: available from the corresponding author, SWC, upon reasonable request; Supplementary data to this article can be found online at https://doi.org/10.1016/j.ncrna.2025.11.006
Code availability: -