circRNA basic information
circBase ID: hsa_circ_0000190
Name: hsa_circ_CNIH4
Synonym: -
Host Gene: CNIH4
Genomic location(hg19): chr1:224553580-224559125:+
Genomic location(hg38): chr1:224365878-224371423:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; adjacent non-tumor tissues; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential non-invasive diagnostic biomarker for gastric cancer; lower expression is associated with tumor diameter, lymphatic metastasis, distal metastasis, TNM stage, and CA19-9 levels.
Molecular mechanism: -
Biological pathway or process:

not specified (other)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis
Clinical significance:

May be a novel non-invasive biomarker for gastric cancer diagnosis; AUC was 0.75 in tissues and 0.60 in plasma, and combined tissue and plasma AUC increased to 0.78; expression was correlated with clinicopathological features including tumor diameter, lymphatic metastasis, distal metastasis, TNM stage, and CA19-9.
Description:

This study evaluated hsa_circ_0000190 as a clinical biomarker for gastric cancer. hsa_circ_0000190 was down-regulated in gastric cancer tissues and patient plasma, and its expression was associated with several clinicopathological factors and showed diagnostic value by ROC analysis.
Confidence score:

0.5662
Other information
Title:

Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer.

Journal: Clinica chimica acta; international journal of clinical chemistry
Published: 2017
PubMed ID: 28130019
Study type:

clinical study
Data availability: GSE89143; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89143
Code availability: -