| Expression pattern: |
UP |
| Associated gene: |
OTUB1, SCD1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes breast cancer cell growth and tumor growth; inhibits ferroptosis; increases cell viability and colony formation; suppresses oxidative stress-induced lipid peroxidation. |
| Molecular mechanism: |
circSCD1 binds the deubiquitinase OTUB1, reduces SCD1 ubiquitination and degradation, and stabilizes SCD1 protein (post-transcriptional regulation). |
| Biological pathway or process: |
ferroptosis (inhibits); proliferation (promotes); ubiquitination (inhibits); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry); RNA Pull-Down; Western Blot; Co-IP; Bioinformatics Analysis |
| Clinical significance: |
CircSCD1 could serve as a foundation for developing circRNA-based diagnostic tools; targeting the circSCD1/OTUB1/SCD1 axis may provide a potential therapeutic strategy for breast cancer treatment. |
| Description: |
circSCD1 is upregulated in breast cancer cell lines and promotes tumor cell viability/proliferation. It suppresses ferroptosis by recruiting the deubiquitinase OTUB1 to reduce SCD1 ubiquitination, stabilizing SCD1 protein and supporting tumor growth in xenograft models. |
| Confidence score: |
0.8344 |