| Expression pattern: |
DN |
| Associated gene: |
AUF1, BIM mRNA, deltaNp63alpha, AGO2 |
| Associated microRNA: |
- |
| Biological function: |
inhibits cisplatin resistance, suppresses proliferation, and promotes cisplatin-mediated apoptosis in CSCC |
| Molecular mechanism: |
circARHGAP5 directly binds AUF1 (RBP decoy), reducing AUF1 availability to bind/degrade BIM mRNA, thereby increasing BIM and promoting cisplatin-mediated apoptosis |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); drug resistance (inhibits); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circARHGAP5 was downregulated in CP-resistant cervical cancer tissues and proposed as a diagnostic biomarker and potential therapeutic approach in CSCC CP resistance |
| Description: |
circARHGAP5 is down-regulated in cisplatin-resistant CSCC tissues and acts as a tumor-suppressive circRNA that increases cisplatin sensitivity. It binds AUF1 in the cytoplasm, limiting AUF1-mediated BIM mRNA decay, thereby elevating BIM and promoting cisplatin-induced apoptosis while reducing proliferation and drug resistance. |
| Confidence score: |
0.7806 |