| Expression pattern: |
UP |
| Associated gene: |
YBX1, FDX1 mRNA, STAT1, LIPT1, ANT2, BAX, Bcl2, mPTP |
| Associated microRNA: |
- |
| Biological function: |
Promotes lung cancer development/progression (increases viability and proliferation, suppresses apoptosis, enhances migration) and inhibits cuproptosis. |
| Molecular mechanism: |
o8G-modified circKIAA1797 is stabilized and exported to cytoplasm by YBX1; circKIAA1797 binds FDX1 mRNA to decrease its stability and expression; circKIAA1797 binds STAT1 protein to inhibit LIPT1 transcription; circKIAA1797 promotes mPTP closure to inhibit cuproptosis. |
| Biological pathway or process: |
cuproptosis (inhibits); proliferation (promotes); apoptosis (inhibits); migration (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; RIP (RNA Immunoprecipitation); CLIP; Co-IP; ChIP / ChIP-seq; RNA Pull-Down; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circKIAA1797 is associated with tumour stage and prognosis, and shows diagnostic potential by ROC analysis (AUC 0.7265). |
| Description: |
In lung cancer, circKIAA1797 (hsa_circ_0003295) is up-regulated and mainly localized in the cytoplasm. It promotes tumor cell viability, proliferation and migration while inhibiting apoptosis, and it suppresses cuproptosis by destabilizing FDX1 mRNA, inhibiting STAT1-driven LIPT1 transcription, and promoting mPTP closure; YBX1 acts as an o8G reader that increases circKIAA1797 stability and cytoplasmic abundance. |
| Confidence score: |
0.8988 |