| Expression pattern: |
DN |
| Associated gene: |
KLF10 |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
Restricts bladder cancer cell proliferation, migration and invasion, and inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-330-3p to upregulate KLF10. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; RNA Pull-Down; FISH / smFISH; Bioinformatics Analysis; Survival Analysis; Transfection; Western Blot |
| Clinical significance: |
High circITGA7 expression in BCa tissues predicted a better overall survival; potential prognostic biomarker. |
| Description: |
CircITGA7 is downregulated in bladder cancer and functions as a tumor suppressor by sponging miR-330-3p, thereby relieving repression of KLF10. Overexpression of circITGA7 inhibits proliferation, migration, invasion in vitro and suppresses xenograft tumor growth, and higher circITGA7 expression correlates with better overall survival. |
| Confidence score: |
0.8174 |