circRNA basic information
circBase ID: hsa_circ_0004470
Name: hsa_circ_MYH9
Synonym: circ_0004470
Host Gene: MYH9
Genomic location(hg19): chr22:36737414-36745300:-
Genomic location(hg38): chr22:36341369-36349255:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissue; adjacent tissue; lung tissue; blood
Cell lines:

H446; A549; H1299; 16HBE; BEAS-2B; H460
In vivo animal model:

cell line-derived xenograft; other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: XPC, DDB1, hHR23B, CDT1
Associated microRNA: -
Biological function: Promotes DNA damage accumulation, inhibits DNA repair, induces S phase arrest, accelerates malignant transformation, promotes proliferation, migration, invasion, and tumorigenic capacity in lung carcinogenesis models.
Molecular mechanism: Binds XPC mRNA to reduce its stability and disrupts XPC-hHR23B complex formation; binds DDB1 and promotes proteasome-dependent DDB1 degradation, thereby deregulating CDT1 and impairing NER and checkpoint control.
Biological pathway or process:

apoptosis (not specified); cell cycle (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); mRNA stability (inhibits); other pathway/process (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Western Blot; IF (Immunofluorescence); RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; Luciferase Reporter Assay; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Cell Cycle Assay; Flow Cytometry（Non-apoptosis/cycle）; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); ELISA
Clinical significance:

Upregulated in lung cancer tissues and blood, suggested as a potential biomarker for lung cancer.
Description:

circ_0004470 (hsa_circ_0004470), derived from MYH9, is upregulated in lung cancer-related cells, animal carcinogen models, and patient tissues/blood. It promotes DNA damage accumulation and S-phase arrest and inhibits DNA repair by binding XPC (reducing XPC mRNA stability and disrupting XPC-hHR23B) and by interacting with DDB1 to drive proteasomal DDB1 degradation and CDT1 dysregulation, thereby promoting malignant transformation and tumor progression.
Confidence score:

0.8861
Other information
Title:

Circular RNA circ_0004470 accelerates the occurrence of lung cancer by promoting DNA damage and cell cycle arrest.

Journal: The Journal of biological chemistry
Published: 2025
PubMed ID: 40157540
Study type:

combined biological and clinical study
Data availability: All data needed to evaluate the conclusions of the study are presented in the paper and/or the Supplementary Materials.
Code availability: -