| Expression pattern: |
UP |
| Associated gene: |
HIF-1A, AGO2, ZEB1 |
| Associated microRNA: |
miR-542-3p |
| Biological function: |
promotes proliferation, migration, invasion and metastasis of hepatocellular carcinoma cells |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-542-3p to regulate HIF-1A; circ-0003006 is induced by transcription factor ZEB1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
circ-0003006 expression was associated with tumor size, histological grade, TNM stage and lymph node metastasis; overexpressed and correlated with poor prognosis. |
| Description: |
circ-0003006 is up-regulated in hepatocellular carcinoma and mainly localized in the cytoplasm. It promotes HCC proliferation and metastasis by sponging miR-542-3p to increase HIF-1A expression, and its expression correlates with adverse clinicopathological features and poor prognosis. |
| Confidence score: |
0.8251 |