circRNA basic information
circBase ID: hsa_circ_0003159
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr7:81689743-81746489:-
Genomic location(hg38): chr7:82060427-82117173:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; adjacent non-tumorous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker; low expression associated with distal metastasis and TNM stage in gastric cancer
Molecular mechanism: -
Biological pathway or process:

metastasis (other)
Detected method:
Q
M
Validation methods:

Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0003159 may be a potential cancer marker for gastric cancer diagnosis; its expression was associated with gender, distal metastasis and TNM stage, with ROC AUC of 0.75
Description:

hsa_circ_0003159 is significantly down-regulated in gastric cancer tissues compared with adjacent non-tumorous tissues. Its lower expression is associated with distal metastasis and TNM stage, and ROC analysis suggests potential diagnostic biomarker value for gastric cancer.
Confidence score:

0.5662
Other information
Title:

Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance.

Journal: Journal of clinical laboratory analysis
Published: 2018
PubMed ID: 28618205
Study type:

clinical study
Data availability: GSE89143; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?ac- c=GSE89143
Code availability: -