| Expression pattern: |
UP |
| Associated gene: |
GRN |
| Associated microRNA: |
miR-140-3p |
| Biological function: |
promotes proliferation, migration, and invasion of HCC cells |
| Molecular mechanism: |
ceRNA sponging of miR-140-3p leading to increased GRN expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot |
| Clinical significance: |
high level of circ_0008274 was associated with larger tumor size and higher TNM stage of the HCC patients |
| Description: |
circ_0008274 is up-regulated in hepatocellular carcinoma and mainly localizes to the cytoplasm. It promotes HCC cell proliferation, migration and invasion by sponging miR-140-3p, thereby relieving repression of GRN and increasing GRN expression. |
| Confidence score: |
0.7283 |