circRNA basic information
circBase ID: -
Name: hsa_circ_CCT3
Synonym: circ-CCT3
Host Gene: CCT3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005008
MONDO name: colorectal adenocarcinoma
Disease details: colorectal adenocarcinoma
Disease DO ID:
 0050861, 0050913
Disease MeSH ID:
 -
Disease NCIt ID:
 C5105
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary colorectal adenocarcinoma tissue; adjacent non-cancerous colorectal tissue / normal colorectal mucosa
Cell lines:

Caco-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Predicts tumor recurrence and poor prognosis (shorter DFS and OS) in colorectal adenocarcinoma.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study
Clinical significance:

High circ-CCT3 expression is associated with poorer disease-free survival (DFS) and overall survival (OS) and independently predicts tumor recurrence (DFS).
Description:

circ-CCT3 is significantly upregulated in colorectal adenocarcinoma tissues versus paired normal tissues. High circ-CCT3 levels are associated with shorter DFS and OS, and circ-CCT3 overexpression independently predicts tumor recurrence (DFS) in multivariate analysis.
Confidence score:

0.6518
Other information
Title:

A Retrospective Study in Colorectal Adenocarcinoma Uncovers the Potential of Circ-CCT3 as a Predictor of Tumor Recurrence.

Journal: Biomedicines
Published: 2025
PubMed ID: 41153715
Study type:

clinical study
Data availability: The data presented in this study are available upon reasonable request from the corresponding authors.
Code availability: -