| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes GC cell proliferation, migration and invasion; inhibits apoptosis; acts as an oncogenic molecule and tumor promoter |
| Molecular mechanism: |
activation of the PI3K/Akt/mTOR signaling pathway, with increased p-PI3K, p-Akt and p-mTOR after hsa_circ_0010882 overexpression and decreased phosphorylated protein levels after hsa_circ_0010882 down-regulation |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high expression is correlated with advanced TNM stage and tumor size; high expression predicts shorter overall survival; independent poor prognostic factor and potential prognostic biomarker |
| Description: |
hsa_circ_0010882 is up-regulated in the plasma of gastric cancer patients and in gastric cancer cell lines. It promotes proliferation, migration and invasion, suppresses apoptosis, and appears to activate the PI3K/Akt/mTOR signaling pathway. Clinically, high hsa_circ_0010882 expression is associated with advanced disease features and poorer overall survival, suggesting prognostic value. |
| Confidence score: |
0.7396 |