| Expression pattern: |
UP |
| Associated gene: |
YBX1 |
| Associated microRNA: |
miR-375 |
| Biological function: |
promotes CC cell proliferation, migration, and pulmonary metastasis; acts as a tumor-promoter in CC |
| Molecular mechanism: |
circ_0002762 functions as a ceRNA by sponging miR-375, negatively regulating miR-375, and upregulating YBX1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
high expression is associated with larger tumor size and lymph node metastasis and implies poor prognosis |
| Description: |
circ_0002762 is up-regulated in cervical carcinoma tissues and cell lines and is associated with larger tumor size and lymph node metastasis. Functionally, circ_0002762 promotes cervical cancer cell proliferation, migration, and pulmonary metastasis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-375 to increase YBX1 mRNA and protein expression. |
| Confidence score: |
0.73 |