| Expression pattern: |
UN |
| Associated gene: |
ZWILCH, RANGAP1, CENPK |
| Associated microRNA: |
hsa-mir-141, hsa-mir-32, hsa-mir-95 |
| Biological function: |
may play important roles in cervical cancer pathogenesis (bioinformatics prediction). |
| Molecular mechanism: |
ceRNA network prediction: circRNA-miRNA-hubgene (ZWILCH/RANGAP1/CENPK) modules. |
| Biological pathway or process: |
cell cycle (other); ceRNA regulation (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
may offer potential therapeutic targets for CC |
| Description: |
This study bioinformatically identified hsa_circ_0084927 as a key circRNA in cervical cancer and constructed predicted ceRNA modules linking it to miR-141/ZWILCH, miR-32/RANGAP1, and miR-95/CENPK. The authors propose it may be involved in CC pathogenesis and represent a potential therapeutic target, but note that experimental validation is still needed. |
| Confidence score: |
0.2465 |