circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: circZNF609
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060198
MONDO name: ischemic stroke
Disease details: ischemic stroke / IS
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Associated with ischemic stroke risk (reduced risk in higher quartiles in adjusted models); potential biomarker in plasma exosomes
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis
Clinical significance:

Plasma exosomal circZNF609 level is associated with ischemic stroke risk and may serve as a biomarker
Description:

This cross-sectional case-control study measured plasma exosomal circZNF609 by RT-qPCR and evaluated its association with ischemic stroke risk. Although overall case-control expression differences were not significant, adjusted regression analyses linked higher circZNF609 quartiles with reduced IS risk, supporting its potential as an exosomal biomarker.
Confidence score:

0.459
Other information
Title:

Molecular epidemiological study of exosomes circZNF609, circPUM1, IGF2 with ischemic stroke.

Journal: BMC cardiovascular disorders
Published: 2025
PubMed ID: 40133811
Study type:

clinical study
Data availability: The data that support the findings of this study are available from the Institute of Chronic Disease Prevention and Control, Wannan Medical College, Anhui Province, but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available.
Code availability: -