circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF91
Synonym: Circ_ZNF91_4
Host Gene: ZNF91
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: Breast Cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumor tissues; Normal Breast Organoids (NBO)
Cell lines:

MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-23b-3p, miR-23a-3p
Biological function: unknown
Molecular mechanism: predicted miRNA response elements (MREs) suggesting potential ceRNA interaction; not experimentally validated
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Up-regulated in ER+ tumors compared to NBO and ER- tumors (luminal subtype association).
Description:

Circ_ZNF91_4 is reported as up-regulated in ER+ breast tumors versus NBO and ER- tumors, suggesting association with the luminal subtype. The study computationally predicts many MREs for miR-23b-3p and miR-23a-3p on this circRNA, but notes these interactions require experimental validation.
Confidence score:

0.1768
Other information
Title:

Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis.

Journal: Oncotarget
Published: 2018
PubMed ID: 29581865
Study type:

combined biological and clinical study
Data availability: GSE52194; GSE101410
Code availability: https://github.com/carlo-deintinis/circhunter