| Expression pattern: |
UP |
| Associated gene: |
SIX1, Vimentin, AGO2 |
| Associated microRNA: |
miR-1306-3p |
| Biological function: |
promotes cell mobility, migration and invasion; promotes tumorigenesis and metastasis in vivo |
| Molecular mechanism: |
ceRNA sponge of miR-1306-3p to relieve repression of SIX1, which transcriptionally upregulates Vimentin |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); proliferation (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circNHSL1 expression correlates with advanced clinicopathological features and poor prognosis; potential diagnostic and prognostic marker |
| Description: |
circNHSL1 is up-regulated in gastric cancer and promotes migration, invasion, tumor growth and metastasis. It functions mainly as a ceRNA by sponging miR-1306-3p to de-repress SIX1, which in turn transcriptionally increases Vimentin expression, driving malignant progression and correlating with poor prognosis. |
| Confidence score: |
0.8766 |