circRNA basic information
circBase ID: hsa_circ_0089131
Name: -
Synonym: circ_0089131
Host Gene: -
Genomic location(hg19): chr9:133738149-133738422:+
Genomic location(hg38): chr9:130862762-130863035:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent non-tumor tissues
Cell lines:

MDA-MB-23A (231-PAR); 231-BM6; LM2; 1833
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TP53
Associated microRNA: miR-378a-3p
Biological function: May play a positive role in the progression of breast cancer; implicated in metastasis and prognosis via a ceRNA network.
Molecular mechanism: ceRNA regulatory network involving hsa_circ_0089131 sponging miR-378a-3p to correlate with TP53, linked to PI3K-Akt/MAPK signaling pathways.
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other); MAPK (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection
Clinical significance:

-
Description:

hsa_circ_0089131 is up-regulated in breast cancer tissues and is proposed to participate in a ceRNA network by associating with miR-378a-3p and TP53. The constructed axis links to PI3K-Akt and MAPK signaling pathways and is discussed in the context of metastasis-related regulation.
Confidence score:

0.4997
Other information
Title:

Integrated analysis of metastasis-related circRNA-miRNA-mRNA ceRNA regulatory network involved in breast cancer.

Journal: Clinics (Sao Paulo, Brazil)
Published: 2025
PubMed ID: 41319483
Study type:

combined biological and clinical study
Data availability: GSE101123; GSE111504; GSE182471; GSE165884; GSE154255; GSE52194
Code availability: -