| Expression pattern: |
DS |
| Associated gene: |
EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Circulating diagnostic biomarker component for GC within an 8-circRNA panel. |
| Molecular mechanism: |
Not experimentally established; discussed potential RBP (EIF4A3) interaction for most panel circRNAs. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Included in 8-circRNA diagnostic model for GC (training AUC 0.87; validation AUC 0.83). |
| Description: |
hsa_circ_0007380 is part of the final 8-circRNA serum diagnostic panel for gastric cancer and contributes to a logistic regression risk model distinguishing GC from controls in training and validation cohorts. Post-surgery decreases for most markers support tumor specificity at the panel level. |
| Confidence score: |
0.6556 |