| Expression pattern: |
UP |
| Associated gene: |
FGFR1, Argonaute 2 |
| Associated microRNA: |
miR-610 |
| Biological function: |
promotes HCC cell viability and colony formation, enhances migration and invasion, promotes cell cycle progression, inhibits apoptosis, and promotes tumor growth in vivo |
| Molecular mechanism: |
circ_0015756 acts as a miRNA sponge for miR-610 to regulate FGFR1 expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0015756 was expected to be a vital indicator in HCC diagnosis and treatment |
| Description: |
circ_0015756 is up-regulated in HCC tissues/serum/cells and promotes malignant phenotypes and xenograft tumor growth. Mechanistically, it sponges miR-610 to de-repress FGFR1, forming a circ_0015756/miR-610/FGFR1 ceRNA axis. |
| Confidence score: |
0.7296 |