circRNA basic information
circBase ID: -
Name: hsa_circ_SPECC1
Synonym: circ_SPECC1
Host Gene: SPECC1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HepG2; Huh7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDK1, PLK1, IL13RA1
Associated microRNA: hsa-let-7c-5p
Biological function: promotes sorafenib resistance; promotes cell cycle-related regulation
Molecular mechanism: Predicted ceRNA-like regulation where circ_SPECC1 interacts with hsa-let-7c-5p, affecting downstream targets CDK1/PLK1 and IL13RA1 linked to cell cycle and JAK-STAT signaling.
Biological pathway or process:

cell cycle (promotes); JAK/STAT (promotes); ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_SPECC1 was identified by RNA-seq/network analysis as up-regulated in sorafenib-resistant HCC cell lines and was proposed to contribute to resistance by interacting with hsa-let-7c-5p and influencing CDK1/PLK1 (cell cycle) and IL13RA1 (JAK-STAT signaling).
Confidence score:

0.1768
Other information
Title:

Exploring the potential mechanisms of sorafenib resistance in hepatocellular carcinoma cell lines based on RNA sequencing.

Journal: Cancer cell international
Published: 2025
PubMed ID: 40082884
Study type:

combined biological and bioinformatics study
Data availability: Supplementary material available at 10.1186/s12935-025-03728-8
Code availability: -