| Expression pattern: |
DN |
| Associated gene: |
PPARalpha, CCL2, AGO2, COX-2, PGE2, FoxO1, CCR2 |
| Associated microRNA: |
miR-580-5p |
| Biological function: |
Inhibits HCC cell proliferation, migration and invasion; inhibits macrophage activation and pro-inflammatory cytokine release in the tumor microenvironment. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-580-5p to modulate PPARalpha and CCL2 secretion; downstream CCL2 activates macrophage COX-2/PGE2 via FoxO1 in a p38 MAPK-dependent manner. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); MAPK (other); ceRNA regulation (promotes); inflammation (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Transwell Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; ELISA; Bioinformatics Analysis |
| Clinical significance: |
Low hsa_circ_0110102 expression was associated with poor prognosis; proposed as a potential prognostic predictor or therapeutic target for HCC. |
| Description: |
hsa_circ_0110102 is down-regulated in HCC and functions as a tumor-suppressive circRNA. It sponges miR-580-5p to modulate the PPARalpha/CCL2 cascade, thereby reducing macrophage COX-2/PGE2 inflammatory activation in the tumor microenvironment and inhibiting HCC proliferation, migration and invasion. |
| Confidence score: |
0.7678 |