circRNA basic information
circBase ID: hsa_circ_0089762
Name: hsa_circ_COX2
Synonym: SCAR / circ_0089762
Host Gene: COX2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent non-tumoral tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PLCG2, SOS1, DTWD2, CPEB4, BTRC, FAM107A, MGLL, FOXJ3, FAM120AOS, AGO1, AGO2, DGCR8, EIF4A3, FMR1, IGF2BP1, IGF2BP2, IGF2BP3, LIN28A, LIN28B, METTL3, TNRC6A
Associated microRNA: hsa-miR-1249, hsa-miR-433, hsa-miR-487a, hsa-miR-554, hsa-miR-938
Biological function: may act as a tumor suppressor; potential diagnostic biomarker for CRC
Molecular mechanism: ceRNA network (predicted) involving SCAR/mc-COX2-miRNA-mRNA axes; predicted RBP interactions (protein sponge activity)
Biological pathway or process:

ceRNA regulation (other); NF-kappaB (other); EGFR (other); immune regulation (other); inflammation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

significant association with pathological T staging; ROC AUC=0.77 (80% sensitivity, 75% specificity) suggesting biomarker potential
Description:

SCAR/mc-COX2 (mc-COX2; hsa-circ-0089762) is significantly down-regulated in CRC tumor tissues and is suggested to act as a tumor suppressor and potential diagnostic biomarker (AUC=0.77). The study predicts a SCAR/mc-COX2-centered ceRNA network involving five miRNAs (including hsa-miR-938 and hsa-miR-1249) and multiple target mRNAs (e.g., MGLL, FAM107A, PLCG2), and also predicts interactions with several RBPs.
Confidence score:

0.459
Other information
Title:

Pathological expression of mitochondrial genome-derived circRNA SCAR/mc-COX2 and its ceRNA network in colorectal cancer: implications for clinical significance.

Journal: BMC cancer
Published: 2025
PubMed ID: 40082804
Study type:

combined biological and clinical study
Data availability: GSE126093; GSE126092; GSE126095
Code availability: -