circRNA basic information
circBase ID: hsa_circ_0001346
Name: hsa_circ_RNF13
Synonym: circRNF13
Host Gene: RNF13
Genomic location(hg19): chr3:149563797-149639014:+
Genomic location(hg38): chr3:149846010-149921227:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-93-5p
Biological function: Decreases after carboplatin and combination therapy in A549 cells; discussed as chemoresistance-related in literature.
Molecular mechanism: Not specified in this study (literature mentions miR-93-5p sponging).
Biological pathway or process:

chemoresistance (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0001346 (circRNF13) is expressed in A549 cells and is significantly reduced after carboplatin and combination treatment, indicating drug-responsive downregulation in this lung cancer cell model. The paper discusses prior reports linking it to miR-93-5p binding and chemoresistance, but does not experimentally validate that mechanism here.
Confidence score:

0.279
Other information
Title:

Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.

Journal: Asian Pacific journal of cancer prevention : APJCP
Published: 2024
PubMed ID: 38918678
Study type:

biological research
Data availability: -
Code availability: -