| Expression pattern: |
UP |
| Associated gene: |
TRIP6, PCNA, cyclin D1, Ki67 |
| Associated microRNA: |
miR-485-3p |
| Biological function: |
Promotes OS cell proliferation, cell-cycle progression, migration, invasion and in vivo tumor growth; knockdown inhibits OS progression. |
| Molecular mechanism: |
circ_0079471 acts as a sponge for miR-485-3p to upregulate TRIP6, thereby promoting OS progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0079471 is proposed as a diagnostic and therapeutic target for OS patients. |
| Description: |
circ_0079471 is up-regulated in osteosarcoma tissues and cells. It promotes OS cell proliferation, cell-cycle progression, migration, invasion and xenograft tumor growth by sponging miR-485-3p and increasing TRIP6 expression. The study suggests circ_0079471 as a potential diagnostic and therapeutic target for OS. |
| Confidence score: |
0.7859 |