| Expression pattern: |
UN |
| Associated gene: |
MARCKS |
| Associated microRNA: |
hsa-miR-218 |
| Biological function: |
Proposed ceRNA regulator in EC-specific programs by sponging hsa-miR-218 and regulating MARCKS (ECM organization, angiogenesis, cell adhesion-related programs). |
| Molecular mechanism: |
Competing endogenous RNA regulation by competitively binding hsa-miR-218 to regulate MARCKS in EC-specific programs. |
| Biological pathway or process: |
ceRNA regulation (other); angiogenesis (other); other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
Suggested as a potential biomarker for CAD. |
| Description: |
The paper proposes that circHERPUD2 participates in an EC-specific ceRNA circuit in CAD by binding hsa-miR-218 and regulating MARCKS, linking it to endothelial programs such as ECM organization and angiogenesis; it is also mentioned as a potential CAD biomarker. |
| Confidence score: |
0.1768 |