circRNA basic information
circBase ID: -
Name: hsa_circ_FUT8
Synonym: hsa_circRNA_101367
Host Gene: FUT8
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood platelets
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: YES1
Associated microRNA: miR-145, miR-944
Biological function: regulates proliferation; invasion; apoptosis of lung cancer cells
Molecular mechanism: miRNA sponging (ceRNA-related) involving miR-145 and miR-944/YES1
Biological pathway or process:

proliferation (other); invasion (other); apoptosis (other); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

In platelets from lung cancer patients, circFUT8 was identified as significantly up-regulated compared with controls. Prior evidence cited by the authors suggests circFUT8 may regulate lung cancer cell proliferation, invasion and apoptosis via miR-145 and the miR-944/YES1 axis.
Confidence score:

0.1768
Other information
Title:

Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection.

Journal: International journal of molecular sciences
Published: 2023
PubMed ID: 36902312
Study type:

combined biological and clinical study
Data availability: GSE225787
Code availability: -