| Expression pattern: |
UN |
| Associated gene: |
SPARC, HSPG2, MGAT4A, APLN, APP |
| Associated microRNA: |
hsa-miR-15a, hsa-miR-15b, hsa-miR-16 |
| Biological function: |
May act as a miRNA sponge in endothelial cells and regulate EC-specific programs linked to endothelial dysfunction in CAD. |
| Molecular mechanism: |
Competing endogenous RNA regulation via miRNA sponging to modulate downstream gene expression in EC-specific programs; potentially disrupted by CAD-associated variant rs6494488. |
| Biological pathway or process: |
ceRNA regulation (other); angiogenesis (other); other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
This study links the CAD GWAS variant rs6494488 to circZNF609 and proposes that circZNF609 acts as a ceRNA in endothelial-cell programs by sponging hsa-miR-15a/15b/16 to regulate targets including SPARC and HSPG2, potentially contributing to endothelial dysfunction in CAD. |
| Confidence score: |
0.1768 |