| Expression pattern: |
UP |
| Associated gene: |
ITGbeta3 |
| Associated microRNA: |
let-7 miRNAs |
| Biological function: |
Supports ITGbeta3 expression and migration in radioresistant TNBC as part of an HNRNPL-derived ceRNA program. |
| Molecular mechanism: |
Acts as a ceRNA with let-7 binding sites (as a group with circRAB12 and circBACE2) to promote ITGbeta3 mRNA stability. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Transfection; Wound Healing Assay; Western Blot; Flow Cytometry（Non-apoptosis/cycle）; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circBIRC6 is upregulated in an HNRNPL-dependent manner in radioresistant TNBC cells and is implicated (with other circRNAs) in let-7 sequestration to stabilize and enhance ITGbeta3 expression, supporting migration. |
| Confidence score: |
0.5607 |