| Expression pattern: |
UP |
| Associated gene: |
CXCR4 |
| Associated microRNA: |
miR-206 |
| Biological function: |
Promotes gastric cancer cell proliferation, survival, migration, invasion, and metastasis; inhibition of circ_0056618 suppresses proliferation and metastasis. |
| Molecular mechanism: |
circ_0056618 acts as a ceRNA by sponging miR-206, thereby promoting CXCR4 expression in gastric cancer. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Western Blot; Transfection; CCK8; MTT; Transwell Assay |
| Clinical significance: |
High circ_0056618 expression is negatively related to gastric cancer patients' survival time and circ_0056618 is a potential gastric cancer prognostic marker and therapeutic target. |
| Description: |
circ_0056618 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with poor patient survival. Functionally, circ_0056618 promotes gastric cancer cell proliferation, invasion, migration, and metastasis. Mechanistically, it acts as a ceRNA by sponging miR-206 to increase CXCR4 expression, suggesting prognostic and therapeutic relevance. |
| Confidence score: |
0.7357 |